I-27: GnRH Agonist Triggering and Luteal Phase Support

author

  • MA Karimzadeh Department of Obstetrics and Gynecology, Research and Clinical Center for Infertility, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
Abstract:

Background GnRH agonist triggering is one of the strategies for ovulation triggering and final maturation of oocytes. So , should be notice for luteal phase support in these cycles. At the first it was began for prevention of severe OHSS but it was associated with luteal phase problem and lower pregnancy rate due to luteolysis effects of GnRH agonists. So, two other alternative strategies have been suggested , the first was dual triggering with GnRH-a and low dose hCG and the second was 1500 units of hCG on the day of oocyte pick up to replace the actions of early luteal LH to sustain implantation and endogenous luteal ovarian steroidogenesis. Sometimes the physician avoids hCG injection and instead focuses on correcting the abnormal luteal steroid profile by providing intensive luteal-phase support with oestradiol and progesterone, Although the pregnancy rate is lower in the fresh embryo transfer but in donor recipient and frozen embryo cycles there was no significant differences between GnRH-a triggering and hCG. It shows that the oocyte quality is not disturbed by GnRH agonist triggering. It may be associated to endometrial gen expression. The endometrial gene expression after the GnRH agonist trigger and a modified luteal phase support( with 1500 IU of hCG on the day of OPU was similar to the pattern seen after the hCG trigger and standard luteal phase support but it does not eliminate the risk of OHSS. However, Regarding the optimal results of segmental IVF, it is recommended to use from GnRH agonist for ovulation triggering and postpone the embryo transfer to the another cycle. MaterialsAndMethods N;Results N;Conclusion N;

Upgrade to premium to download articles

Sign up to access the full text

Already have an account?login

similar resources

Luteal phase support after GnRH triggering in IVF cycles

Corespondență: Dr. Andreea Carp Velișcu e-mail: andreea_veliscu@ yahoo.com Introduction. The luteal phase in IVF stimulated cycles is very different from that in natural cycles, so is very important to mimic the perfect condition for pregnancy. Method. Since January 2015 until December 2015, we have 88 cycles in which the triggering was done with GnRH agonist. We performed an embriotransfer in ...

full text

The luteal phase after GnRH-agonist triggering of ovulation: present and future perspectives.

In stimulated IVF/intracytoplasmic sperm injection cycles, the luteal phase is disrupted, necessitating luteal-phase supplementation. The most plausible reason behind this is the ovarian multifollicular development obtained after ovarian stimulation, resulting in supraphysiological steroid concentrations and consecutive inhibition of LH secretion by the pituitary via negative feedback at the le...

full text

Impact of Mid-Luteal Phase GnRH Agonist Administration on Reproductive Outcomes in GnRH Agonist-Triggered Cycles: A Randomized Controlled Trial

OBJECTIVE To explore whether the addition of a mid-luteal bolus of GnRH agonist (GnRHa) improves the implantation rate (IR) in in vitro fertilization (IVF) cycles. DESIGN A randomized controlled trial. SETTING Private IVF center. PATIENTS 328 IVF/intracytoplasmic sperm injection patients were triggered with GnRHa and received 1,500 IU HCG on the day of oocyte pick-up (OPU) in addition to ...

full text

Luteal phase support with gonadotropin-releasing hormone agonist.

Kung et al authored a valuable article entitled “Luteal phase support with decapeptyl improves pregnancy outcomes in ICSI with basal FSH >8 mIU/mL or mature oocytes 3”. This retrospective study enrolled 240 patients who underwent intracytoplasmic sperm injection (ICSI). One hundred and forty-seven patients were in the decapeptyl group and 93 patients were in the control group. The authors inves...

full text

GnRH agonist for luteal support in IVF? Setting the balance between enthusiasm and caution.

2580 © The Author 2006. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. All rights reserved. For Permissions, please email: [email protected] Associate editor’s commentary on ‘Beneficial effect of luteal-phase GnRH agonist administration on embryo implantation after ICSI in both GnRH agonistand antagonist-treated...

full text

My Resources

Save resource for easier access later

Save to my library Already added to my library

{@ msg_add @}


Journal title

volume 9  issue 2

pages  17- 17

publication date 2015-09-01

By following a journal you will be notified via email when a new issue of this journal is published.

Hosted on Doprax cloud platform doprax.com

copyright © 2015-2023